Biological Pathway Hub

Growth Hormone Secretagogues & GHRH

Anterior Pituitary Somatotroph Receptors & Pulsatile Endocrine Cascades

Analytical biochemical profiles for synthetic growth hormone secretagogue receptor (GHSR-1a) agonists and growth hormone-releasing hormone (GHRH) analogues evaluated for selective pituitary signaling and downstream IGF-1 transcription.

Signaling Focus: GHSR-1a selective receptor binding, GHRH receptor signal transduction, pulsatile somatotroph release, minimal endocrine off-target elevation.

2 Compound Monographs Indexed

Reagents in this Signaling Category

Mixed Pre-ClinicalCAS 863288-34-0

CJC-1295

Modified Growth Hormone-Releasing Hormone (Mod GRF 1-29 / CJC-1295 No DAC)

C152H252N44O423367.97 g/molGrowth Hormone Secretagogues & GHRH

CJC-1295 (Mod GRF 1-29) is a synthetic 29-amino-acid analogue of human growth hormone-releasing factor featuring four D-amino acid substitutions to enhance metabolic stability against dipeptidyl peptidase-4 (DPP-4). Evaluated in UK endocrine research for pulsatile somatotroph signaling.

Verified UK Sourcing Partners:

PharmaGrade Store (≥99.2% (HPLC))Direct Peptides (≥99.0% (HPLC))Direct Sarms (≥98.6% (HPLC))Peptide Works (≥98.8% (HPLC))PharmaLab Global (≥99.4% (HPLC))

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Human Trial DataCAS 170851-70-4

Ipamorelin

Aib-His-D-2-Nal-D-Phe-Lys-NH2 Pentapeptide

C38H49N9O5711.86 g/molGrowth Hormone Secretagogues & GHRH

Ipamorelin is a synthetic pentapeptide and selective ghrelin receptor (GHSR-1a) agonist. Distinct from earlier GHRPs due to its selectivity: it stimulates somatotroph growth hormone release in vitro without triggering substantial elevation in cortisol, prolactin, or ACTH.

Verified UK Sourcing Partners:

PharmaGrade Store (≥99.3% (HPLC))Direct Peptides (≥99.1% (HPLC))Direct Sarms (≥98.8% (HPLC))Peptide Works (≥99.0% (HPLC))PharmaLab Global (≥99.5% (HPLC))

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